Software for determining the 3D structure of proteins

Tuesday, Nov 3, 2020
by tdwyer

Software for determining the 3D structure of proteins

Catherine Zandonella, Office of the Dean for Research, Nov. 3, 2020

A new software package aims to aid drug design and biomedical research by making it easy to construct 3D images of proteins and other molecules using one of the world’s most powerful microscopes.

Amit Singer, professor of mathematics and the Program in Applied and Computational Mathematics, and his team are developing a package they call Algorithms for Single Particle Reconstruction, or ASPIRE, that takes in 2D images captured by cryo-electron microscopy and produces reliable 3D structures without significant human intervention.

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