Title: Heterogeneity in Cryo-EM
Abstract: Cryo-electron microscopy is a method of imaging proteins. Driven by improvements in microscopes and computational power, it is rapidly becoming more and more important to structural biology. One of the central assumptions in classical cryo-EM, however, is that the protein is structurally homogeneous, meaning that it is found in only one structural pose (or "conformation"). However, proteins are often found in many poses; this is called the heterogeneity problem in cryo-EM and doesn't work with traditional methods. In my talk I will give an overview of the cryo-EM process, as well as discuss a geometric learning-based approach for reconstruction with heterogeneity.